
Lithium is best known as a mood-stabilizing medication; however, several newer studies are suggesting it may also have a powerful role in protecting the aging brain, especially against Alzheimer’s disease. Researchers have found that lithium seems to help the brain keep doing its “housekeeping” jobs: clearing out amyloid plaques and tau tangles, supporting healthy nerve cells, and even helping brain immune cells work better. In fact, a 2025 Nature paper showed that people (and mice) with lower lithium in the brain showed earlier Alzheimer’s-type changes, and restoring lithium to gentle, physiologic levels helped prevent or reverse some of those changes.
This lines up with earlier clinical and population studies showing that people on long-term lithium for mood disorders had a lower risk of developing dementia, and that even very low–dose (sometimes called “microdose”) lithium helped stabilize people with mild cognitive impairment — a common early stage before Alzheimer’s. The proposed mechanism? Lithium inhibits the enzyme GSK-3, which is involved in tau tangle formation, and reduces inflammation and oxidative stress in the brain. Together, these effects make lithium look like a potential “disease-modifying” tool, not just a symptom reliever.
How to apply this (safely)
No self-dosing: prescription-strength lithium can affect the kidneys and thyroid, so no one should start it without a healthcare provider who can check blood levels.
Ask about low-dose options: some studies used much lower doses than those used for bipolar disorder — your provider can tell you what’s safe for you.
Support your brain in parallel: an anti-inflammatory, whole-food, plant-based diet, movement, sleep, and blood sugar control all work with lithium’s neuroprotective effects.
Watch for trials: because these findings are exciting but still emerging, people at higher risk of Alzheimer’s (family history, MCI) may want to follow or join clinical studies as they open.
Dr. T’s Take: Lithium is not a DIY supplement for brain health — but it is one of the most intriguing, evidence-supported “old” therapies being rediscovered for Alzheimer’s prevention and slowing, and it’s worth a conversation with a knowledgeable practitioner. Click on original study below to read more details.



